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ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis

Frontiers of Medicine   Pages 972-992 doi: 10.1007/s11684-023-0990-1

Abstract: In addition, ADT-OH restored intestinal microbiota dysbiosis characterized by the significantly increasedTransplanting ADT-OH-modulated microbiota can alleviate DSS-induced colitis and negatively regulate the

Keywords： inflammatory bowel disease     ADT-OH     intestinal permeability     gut microbiota    

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Gut microbiota and its implications in small bowel transplantation

Chenyang Wang, Qiurong Li, Jieshou Li

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 239-248 doi: 10.1007/s11684-018-0617-0

Abstract:

The gut microbiota is mainly composed of a diverse population of commensal bacterial species and playsThe influence of the gut microbiota on solid organ transplantation has recently been recognized.Furthermore, we explored the potential of the gut microbiota as a microbial marker and/or therapeuticGiven that current research on the gut microbiota has become increasingly sophisticated and comprehensiveThe findings are expected to provide valuable insights into the role of gut microbiota in the development

Keywords： gut microbiota     small bowel transplantation     acute rejection     chronic rejection     mucosal immunity     biomarker     microbiota-targeted therapy    

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Pien Tze Huang Protects Against Non-Alcoholic Steatohepatitis by Modulating the Gut Microbiota and Metabolites

Xianyi Zeng,Xiang Zhang,Hao Su,Hongyan Gou,Harry Cheuk-Hay Lau,Xiaoxu Hu,Ziheng Huang,Yan Li,Jun Yu,

Engineering doi: 10.1016/j.eng.2022.10.010

Abstract: Through the metagenomic sequencing of stool samples, we found that PTH administration restored the gutmicrobiota with enrichment of probiotics including Lactobacillus acidophilus (L. acidophilus), LactobacillusIn addition, PTH restored the gut barrier function in mice with steatohepatitis, as evidenced by reducedWe further confirmed that an intact gut microbiota is necessary for PTH to exhibit anti-steatohepatitisIn conclusion, PTH protects against steatohepatitis development by modulating the gut microbiota and

Keywords： Pien Tze Huang     Non-alcoholic steatohepatitis     Gut barrier function     Gut microbiota    

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Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota

Ruiting Han, Junli Ma, Houkai Li

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 645-657 doi: 10.1007/s11684-018-0645-9

Abstract: disease because of the intricate role of gut microbiota in maintaining human health and disease formationMoreover, gut microbiota is even regarded as a “metabolic organ” that play complementary roles to thatAs a result, gut microbiota have been emerging as a novel therapeutic target for NAFLD by manipulatingIn this review, we summarized the most recent advances in gut microbiota-mediated mechanisms, as wellas gut microbiota-targeted therapies on NAFLD.

Keywords： gut microbiota     NAFLD     obesity     insulin resistance     bile acids     probiotic    

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Calorie restriction and its impact on gut microbial composition and global metabolism

Xiaojiao Zheng, Shouli Wang, Wei Jia

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 634-644 doi: 10.1007/s11684-018-0670-8

Abstract: In the present review, we focus on the general effect of CR on gut microbiota composition and globalAnalyses of the gut microbial and host metabolisms revealed that most host microbial co-metabolites wereThe observed phenotypes and the further verification of the direct link between gut microbiota and metabolomeThus, improved gut microbiota composition and metabolome are potential biomarkers for determining the

Keywords： caloric restriction     gut microbiota     metabolome    

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Treating Chronic Diseases by Regulating the Gut Microbiota

Bin Hong, Jian-Dong Jiang

Engineering 2022, Volume 18, Issue 11,   Pages 17-20 doi: 10.1016/j.eng.2021.08.015

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Altered intestinal microbiota associated with colorectal cancer

Hong Zhang, Ying Chang, Qingqing Zheng, Rong Zhang, Cheng Hu, Weiping Jia

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 461-470 doi: 10.1007/s11684-019-0695-7

Abstract: The gut microbiota plays an important role in the development and progression of colorectal cancer (CRCTo learn more about the dysbiosis of carcinogenesis, we assessed alterations in gut microbiota in patientsreduction in which is a butyrate-producing genera of bacteria, and a significant increase in in the gutmicrobiota of CRC patients.Different levels of gut microflora in healthy and CRC samples were identified.

Keywords： colorectal cancer (CRC)     gut microbiota     intestinal     Eubacterium     Devosia    

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The Gut Microbiota, Tumorigenesis, and Liver Diseases

Guishuai Lv, Ningtao Cheng, Hongyang Wang

Engineering 2017, Volume 3, Issue 1,   Pages 110-114 doi: 10.1016/J.ENG.2017.01.017

Abstract:

In recent decades, diseases concerning the gut microbiota have presented some of the most seriousExtensive epidemiological studies have revealed that there is a strong link between the gut microbiotaRelevant animal studies involving gut microbiota manipulations, combined with observational studies onStudies of the composition and function of the gut microbiota could shed some light on understandingHere, we provide an overview of the relationships among the gut microbiota, tumors, and liver diseases

Keywords： Gut microbiota     Dysbiosis     Tumorigenesis     Hepatocellular carcinoma     Nonalcoholic fatty liver disease    

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Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 307-321 doi: 10.1007/s11684-022-0927-0

Abstract: Studies have shown that the gut microbiota is essential for the interaction between immune checkpointantibiotics, with an in-depth discussion about the mechanisms and therapeutic potential of modulating gutmicrobiota, as well as other new combination strategies.

Keywords： tumor immunotherapy     immune checkpoint inhibitor     antibiotics     gut microbiota     drug–drug interaction    

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The Fish Microbiota: Research Progress and Potential Applications Review

Yinyin Luan, Ming Li, Wei Zhou, Yuanyuan Yao, Yalin Yang, Zhen Zhang, Einar Ringø, Rolf Erik Olsen, Jihong Liu Clarke, Shouqi Xie, Kangsen Mai, Chao Ran, Zhigang Zhou

Engineering 2023, Volume 29, Issue 10,   Pages 137-146 doi: 10.1016/j.eng.2022.12.011

Abstract:

The gut microbiota plays an important role in host health and diseaseNevertheless, research has highlighted the importance of the microbiota in the health, performance, andThe composition of the fish microbiota depends on host selection, diet, and environmental factors.In this review, we discuss recent progress in fish microbiota research.fundamental research extending our knowledge of host–microbiota interaction in fish.

Keywords： Gut microbiota     Fish     Host–microbiota interaction     Aquaculture    

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Gut Microbiota Modulation: A Viable Strategy to Address Medical Needs in Hepatocellular Carcinoma and Review

Ze Xiang, Jian Wu, Jiarui Li, Shusen Zheng, Xuyong Wei, Xiao Xu

Engineering 2023, Volume 29, Issue 10,   Pages 59-72 doi: 10.1016/j.eng.2022.12.012

Abstract: Gut microbiota, an emerging field of research, also plays a crucial role.Through the microbiome–gut–liver axis, the gut microbiota has an impact on the onset andIn addition, gut microbiota alterations after LT were reviewed, and the relationship between the gutIn the era of LT oncology, the role of the gut microbiota in HCC and LT should be emphasized, which canprovide new insights into the management of HCC and LT via gut microbiota modulation.

Keywords： Gut microbiota     Hepatocellular carcinoma (HCC)     Liver transplantation (LT)     Clinical value     Mediating    

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Modulation of Gut Microbiota in Pathological States

Yulan Wang, Baohong Wang, Junfang Wu, Xiangyang Jiang, Huiru Tang, Ole H. Nielsen

Engineering 2017, Volume 3, Issue 1,   Pages 83-89 doi: 10.1016/J.ENG.2017.01.013

Abstract: Our gut microbiota evolves with us and plays a pivotal role in human health and disease.The gut microbiota may be linked to malignancies such as gastric cancer and colorectal cancer.microbiota more accurately, we need to elucidate the relationships between the gut microbiota and severalmicrobiota for human health and the potential to manipulate gut microbial composition for purposes suchThe concept of altering the gut community by microbial intervention in an effort to improve health is

Keywords： Gut microbes     Diseases     Microbial modulation    

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Targeting Gut Microbiota Dysbiosis: Potential Intervention Strategies for Neurological Disorders Review

Wanqiang Wu, Qingmin Kong, Peijun Tian, Qixiao Zhai, Gang Wang, Xiaoming Liu, Jianxin Zhao, Hao Zhang, Yuan Kun Lee, Wei Chen

Engineering 2020, Volume 6, Issue 4,   Pages 415-423 doi: 10.1016/j.eng.2019.07.026

Abstract:

It is well known that the gut microbiota plays an extremely important role in modulating host physiologicalIn recent years, accumulated evidence has revealed that the gut microbiota can regulate the functionsThis review focuses on the molecular mechanism of the crosstalk between the gut microbiota and the braingut microbiota dysbiosis.the molecular mechanism that underlies how the gut microbiota regulates neurological functions not only

Keywords： Gut microbiota     Gut–brain axis     Neurological disorders     Intervention strategies    

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Gut Microbiota Community Shift with Severity of Coronary Artery Disease Article

Jia-Lu Hu, Zhi-Feng Yao, Min-Na Tang, Chun Tang, Xiao-Fan Zhao, Xi Su, Dan-Bo Lu, Qiu-Rong Li, Zhang-Sheng Wang, Yan Yan, Zeneng Wang

Engineering 2021, Volume 7, Issue 12,   Pages 1715-1724 doi: 10.1016/j.eng.2020.05.025

Abstract:

Gut microbiota community shift with coronary artery disease (CAD) has been reported in several limitedHowever, whether the enriched or decreased microbiota taxa with CAD can be reproducible deserves furtherHowever, the non-reproducibility of the microbiota taxa enriched in CAD across different cohorts limits

Keywords： Gut microbiota     Atherosclerosis     Coronary artery disease    

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Multi-Omics Analysis Provides Insight into the Possible Molecular Mechanism of Hay Fever Based on GutMicrobiota Article

Pei Han, Li-Sha Li, Zi-Xi Wang, Lin Xi, Hang Yu, Lin Cong, Zheng-Wei Zhang, Jie Fu, Ran Peng, Li-Bin Pan, Shu-Rong Ma, Xue-Yan Wang, Hong-Tian Wang, Xiang-Dong Wang, Yan Wang, Jin-Lyu Sun, Jian-Dong Jiang

Engineering 2022, Volume 15, Issue 8,   Pages 115-125 doi: 10.1016/j.eng.2021.03.013

Abstract: As allergic disease has been associated with gut dysbiosis, we searched for a possible mechanism fromthe perspective of the molecular interface between host and microbiota with concurrent metabolomicsderivatives (especially valine, and IPA which is the reductive product of tryptophan) , SCFAs, and the gut

Keywords： Metabolome     Gut microbiota     Hay fever     Allergic diseases     Intestinal barrier dysfunction    

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Title Author Date Type Operation

ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis

Journal Article

Gut microbiota and its implications in small bowel transplantation

Chenyang Wang, Qiurong Li, Jieshou Li

Journal Article

Pien Tze Huang Protects Against Non-Alcoholic Steatohepatitis by Modulating the Gut Microbiota and Metabolites

Xianyi Zeng,Xiang Zhang,Hao Su,Hongyan Gou,Harry Cheuk-Hay Lau,Xiaoxu Hu,Ziheng Huang,Yan Li,Jun Yu,

Journal Article

Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota

Ruiting Han, Junli Ma, Houkai Li

Journal Article

Calorie restriction and its impact on gut microbial composition and global metabolism

Xiaojiao Zheng, Shouli Wang, Wei Jia

Journal Article

Treating Chronic Diseases by Regulating the Gut Microbiota

Bin Hong, Jian-Dong Jiang

Journal Article

Altered intestinal microbiota associated with colorectal cancer

Hong Zhang, Ying Chang, Qingqing Zheng, Rong Zhang, Cheng Hu, Weiping Jia

Journal Article

The Gut Microbiota, Tumorigenesis, and Liver Diseases

Guishuai Lv, Ningtao Cheng, Hongyang Wang

Journal Article

Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy

Journal Article

The Fish Microbiota: Research Progress and Potential Applications

Yinyin Luan, Ming Li, Wei Zhou, Yuanyuan Yao, Yalin Yang, Zhen Zhang, Einar Ringø, Rolf Erik Olsen, Jihong Liu Clarke, Shouqi Xie, Kangsen Mai, Chao Ran, Zhigang Zhou

Journal Article

Gut Microbiota Modulation: A Viable Strategy to Address Medical Needs in Hepatocellular Carcinoma and

Ze Xiang, Jian Wu, Jiarui Li, Shusen Zheng, Xuyong Wei, Xiao Xu

Journal Article

Modulation of Gut Microbiota in Pathological States

Yulan Wang, Baohong Wang, Junfang Wu, Xiangyang Jiang, Huiru Tang, Ole H. Nielsen

Journal Article

Targeting Gut Microbiota Dysbiosis: Potential Intervention Strategies for Neurological Disorders

Wanqiang Wu, Qingmin Kong, Peijun Tian, Qixiao Zhai, Gang Wang, Xiaoming Liu, Jianxin Zhao, Hao Zhang, Yuan Kun Lee, Wei Chen

Journal Article

Gut Microbiota Community Shift with Severity of Coronary Artery Disease

Jia-Lu Hu, Zhi-Feng Yao, Min-Na Tang, Chun Tang, Xiao-Fan Zhao, Xi Su, Dan-Bo Lu, Qiu-Rong Li, Zhang-Sheng Wang, Yan Yan, Zeneng Wang

Journal Article

Multi-Omics Analysis Provides Insight into the Possible Molecular Mechanism of Hay Fever Based on GutMicrobiota

Pei Han, Li-Sha Li, Zi-Xi Wang, Lin Xi, Hang Yu, Lin Cong, Zheng-Wei Zhang, Jie Fu, Ran Peng, Li-Bin Pan, Shu-Rong Ma, Xue-Yan Wang, Hong-Tian Wang, Xiang-Dong Wang, Yan Wang, Jin-Lyu Sun, Jian-Dong Jiang

Journal Article